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dc.contributor.authorPatch, Megan
dc.date.accessioned2014-03-04T18:57:14Z
dc.date.available2014-03-04T18:57:14Z
dc.date.issued2010-08
dc.identifier.otherpatch_megan_201008_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/patch_megan_201008_ms
dc.identifier.urihttp://hdl.handle.net/10724/26743
dc.description.abstractCurrent DNA comparisons focus on single gene alignments to reconstruct a phylogenetic tree. Standard phylogenetic methods based on sequence alignments are not always applicable to plasmids because many plasmids do not share homologous genes. To overcome this limitation, sequence alignment methods are combined with genome signature, facilitating the comparison of any DNA sequences regardless of the presence of homologous genes. Nucleotide alignment, amino acid alignment, and genome signature are integrated to combine vertical evolutionary history, which reflects shared ancestry with horizontal evolutionary, which reflects shared hosts.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectGenome Signature
dc.subjectPhylogeny
dc.subjectPlasmid
dc.subjectDNA Sequence Comparison
dc.subjectEvolutionary Tree
dc.titleInvestigation of evolutionary relationships of plasmids by combining sequence alignments with genome signature
dc.typeThesis
dc.description.degreeMS
dc.description.departmentMicrobiology
dc.description.majorMicrobiology
dc.description.advisorJan Mrazek
dc.description.committeeJan Mrazek
dc.description.committeeWilliam B. Whitman
dc.description.committeeTimothy Hoover


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