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dc.contributor.authorHeidorn, Neely Lynn
dc.date.accessioned2014-03-04T18:56:09Z
dc.date.available2014-03-04T18:56:09Z
dc.date.issued2010-08
dc.identifier.otherheidorn_neely_l_201008_phd
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/heidorn_neely_l_201008_phd
dc.identifier.urihttp://hdl.handle.net/10724/26650
dc.description.abstractGonadotropin-inhibitory hormone (GnIH) is a hypothalamic RFamide-related peptide that inhibits gonadotropin release in birds. The orthologous RFamide gene sequence and function of GnIH in the pig is not known. A partial cDNA was isolated for the porcine Rfrp gene and the amino acid sequence identified to reveal that the porcine gene codes for the RFamide peptides; RFRP-1 and RFPR-3, and RFRP-2. Using immunohistochemistry, RFamide containing neurons within the porcine hypothalamus were most abundant in the supraoptic nucleus, lateral preoptic area, and the paraventricular nucleus. Peripheral administration of RFRP-3 to ovariectomized (OVX) prepubertal gilts reduced LH pulse amplitude and mean concentrations of LH after treatment. Central administration of RFRP-3 to OVX prepubertal gilts suppressed amplitude and frequency of LH pulses. These data suggest that RFRP-3can regulate pulsatile secretion of LH in the OVX prepubertal gilt.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectRFamide peptide, pig, LH, GnIH, gene, immunohistochemistry, hypothalamus, RFRP-3
dc.titleThe role of RF-amide related peptide-3 in the control of LH secretion in the ovariectomized prepubertal gilt
dc.typeDissertation
dc.description.degreePhD
dc.description.departmentAnimal and Dairy Science
dc.description.majorAnimal and Dairy Science
dc.description.advisorClay Lents
dc.description.committeeClay Lents
dc.description.committeeSteven Stice
dc.description.committeeGaylen Edwards
dc.description.committeeRichard Barb
dc.description.committeeMichael Azain


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