Temporal and spatial distribution of antibodies to a novel epizootic hemorrhagic disease virus (EHDV-6) in white-tailed deer (Odocoileus virginianus) populations in the Eastern United States
Hecht, Aaron Nicholas
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During 2006, six epizootic hemorrhagic disease viruses (EHDV) recovered from white-tailed deer (Odocoileus virginianus) in Indiana and Illinois were identified as EHDV-6, an exotic virus to North America. Genetic analysis revealed that the isolates were a novel reassortment of EHDV- 2 (structural and nonstructural components) and EHDV-6 (antigenic characteristics). Currently, little is known about the temporal and spatial distribution of EHDV-6. A total of 1,133 serum samples collected from deer from 2000-2009 were tested for neutralizing antibodies to EHDV-1, -2, and -6. Neutralizing antibodies to EHDV-6 were detected in 32 samples, but only three samples were classified as positive because two deer had low titer (1:10) reactions and the remaining 27 samples had neutralizing antibodies to EHDV-1 and/or EHDV-2 at a similar or higher dilution. These results indicate that antibodies to EHDV-6 are rare in deer but the potential impact this exotic serotype will have on domestic and wild ruminant populations is currently unknown.