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dc.contributor.authorAtwell, Lauren Lee
dc.date.accessioned2014-03-04T18:55:06Z
dc.date.available2014-03-04T18:55:06Z
dc.date.issued2010-08
dc.identifier.otheratwell_lauren_l_201008_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/atwell_lauren_l_201008_ms
dc.identifier.urihttp://hdl.handle.net/10724/26559
dc.description.abstractThis study tested if zinc supplementation can induce changes in serum protein levels. Hypothesis: Early pubertal, Caucasian girls taking 24 mg oral zinc sulfate for 30 days have different contents of serum proteins than matched controls taking a placebo. Twelve, healthy, well-nourished girls, ages 9-11, were selected from an ongoing, randomized, placebo-controlled trial and matched based on maturity offset (years to peak height velocity), body weight (kg), and Tanner stage of maturation. High abundance proteins were removed using Seppro® IgY 14 Spin Columns. Two-dimensional electrophoresis (2-DE) and mass spectrometry (MS) were used to identify changes in serum proteins among baseline and four-week samples. Ten proteins were differentially expressed in the zinc supplementation group. These proteins may serve as biomarkers for zinc status in humans. Future research is necessary to validate these candidate biomarkers and to characterize their roles in zinc metabolism and responses to zinc supplementation.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectZinc
dc.subjectZinc supplementation
dc.subjectBiomarker
dc.subjectProtein analysis
dc.subjectPrefractionation
dc.subjectZinc sulfate
dc.subjectHealthy
dc.subjectEarly pubertal
dc.subjectCaucasian
dc.subjectSerum proteins
dc.subjectSDS-PAGE
dc.subjectMaturity offset
dc.subject2DE
dc.subjectProteomics
dc.subject2D
dc.subjectGirls
dc.subjectFemales
dc.titleEffect of short-term oral zinc supplementation on serum protein content in early pubertal, Caucasian females
dc.title.alternativea search for candidate biomarkers
dc.typeThesis
dc.description.degreeMS
dc.description.departmentFoods and Nutrition
dc.description.majorFoods and Nutrition
dc.description.advisorArthur Grider
dc.description.committeeArthur Grider
dc.description.committeeRichard Lewis
dc.description.committeeJames Hargrove


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