The relationship between DNA methylation and nucleosome occupancy involving in a transcriptional activity of SOX2
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Histone modifications, DNA methylation, and nucleosome occupancy are known to play an important role in regulation of transcription. The purpose of the study was to comprehend the relationship between DNA methylation and nucleosome occupancy on the promoter of SOX2. Since current studies showed that the more cells are differentiated, the more the promoter of SOX2 is methylated and occupied by nucleosomes, we sought to characterize the relationship between DNA methylation and nucleosome occupancy involved in transcriptional activity of SOX2 in H9 embryonic stem cells, H9 cardiac progenitor cells, H0 smooth muscle cells, and Hela cells. Our experimental data for Hela cells supports data from current studies that transcriptional silencing may include interactions between DNA methylation and nucleosomes.