Show simple item record

dc.contributor.authorHarris, Kyle
dc.date.accessioned2014-03-04T18:28:04Z
dc.date.available2014-03-04T18:28:04Z
dc.date.issued2010-05
dc.identifier.otherharris_kyle_201005_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/harris_kyle_201005_ms
dc.identifier.urihttp://hdl.handle.net/10724/26343
dc.description.abstractSeveral hydroxyquinoline-protected acetates were synthesized to study how changes in substituents at C-8 affect their ground-state and excited-state chemistry and photoreactivity. Strong electron withdrawing groups form a greater proportion of the anionic form of the quinoline at neutral pH. A photoremovable protecting group for carbonyl compounds, Bhc-dithiol, should be more resistant to hydrolysis in the dark than Bhc-diol. The synthesis of a protected version of Bhc-dithiol is described. A CyHQ-based linker for the activation of morpholinos was synthesized for use in spatio-temporal studies of gene expression in developing zebrafish embryos. This cyano-based derivative of BHQ has a three-fold higher molar absorptivity than BHQ and higher sensitivity to one-photon excitation, which will enable more efficient photoactivation of the morpholino than a previous BHQ-based-linker analog.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectCyHQ, Caged morpholino, XHQ-OAc, Bhc-dithiol, Photoremovable Protecting Group, PPG
dc.titleA CyHQ-linker for the controlled spatiotemporal study of gene expression in zebrafish
dc.typeThesis
dc.description.degreeMS
dc.description.departmentChemistry
dc.description.majorChemistry
dc.description.advisorTimothy Dore
dc.description.committeeTimothy Dore
dc.description.committeeVladimir V. Popik
dc.description.committeeRobert Phillips
dc.description.committeeGeorge Majetich


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record