Pharmacokinetic evaluation of investigational agents obtained from bioactive marine natural products, chemical synthesis and reformulation
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Pharmacokinetics is the science dedicated to the study of rate processes such as absorption, distribution, metabolism, and excretion (ADME) of a drug and the multiple interrelationships affecting them, such as incomplete absorption, saturability in transport, biotransformation, or binding. It is becoming increasingly clear that utilizing pharmcokinetic tools to evaluate large numbers of compounds for ADME properties early in the drug discovery process will ultimately save considerable time and money for pharmaceutical and biotechnology companies, but also to improve the likelihood of success. In this dissertation, pharmacokinetic evaluations were performed for investigational agents obtained from bioactive marine natural products, chemical synthesis and reformulation.