• Login
    View Item 
    •   Athenaeum Home
    • University of Georgia Theses and Dissertations
    • University of Georgia Theses and Dissertations
    • View Item
    •   Athenaeum Home
    • University of Georgia Theses and Dissertations
    • University of Georgia Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    NMR based studies of metabolic process

    Thumbnail
    Date
    2009-12
    Author
    Varatharajan, Janani
    Metadata
    Show full item record
    Abstract
    Metabonomics, the study of small molecule metabolic profiles, together with proteomic and transcriptomic information gives a rich picture of the function of living organisms. In order to understand the function of the multiple enzymes involved in these systems we need massive quantities of real-time data. This often requires the development of new analysis procedures that can model interactions of multiple components. The methodology presented here is based on Nuclear Magnetic Resonance (NMR) observation of real time variation of metabolites, on new spectral analysis methods that can deconvolute the signatures of each molecular species, and network modeling methods that can identify interactions in complex systems. As a model system, the enzyme acetyl-CoA synthetase is selected. The role of this enzyme is to activate acetate to acetyl-coenzyme A (Ac-CoA). The importance of this enzyme is that it provides the cell a two-carbon metabolite which can be used in energy generation processes and functional modification of both proteins and carbohydrates.
    URI
    http://purl.galileo.usg.edu/uga_etd/varatharajan_janani_200912_ms
    http://hdl.handle.net/10724/26176
    Collections
    • University of Georgia Theses and Dissertations

    About Athenaeum | Contact Us | Send Feedback
     

     

    Browse

    All of AthenaeumCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    About Athenaeum | Contact Us | Send Feedback