Show simple item record

dc.contributor.authorSmith, Maren
dc.description.abstractThe Y chromosome is a non-recombining, patrilineal chromosome that is comprised of a few male specific genes, repetitive sequences, and transposable elements (Graves 2006). It is well known for its role in sex determination and male fertility, but recent research revealed a new activity for the Y chromosome: control of gene expression on other chromosomes in the genome. In 2008 Benardo Lemos discovered that, in Drosophila melanogaster, polymorphisms on the Y chromosome have differential effects on expression of autosomal and X-linked genes. Many of these genes are involved in pathways related to cellular stability and repair, which are mechanisms that have a role in the aging process. This led to the hypothesis that the Y chromosome may have an influence on aging. To study this possibility we created an isogenic line of D. melanogaster, and introduced eighteen Y chromosomes to this line: nine from African populations and nine from North American populations. We measured senescence in these flies by monitoring death rate over a 60 day period. We found significant variation in rate of aging in both male and female flies, hinting at the complex nature of studies of the aging process.
dc.subjectSenescence, Y chromosome, Drosophila melanogaster, aging
dc.titleSenescence and the Y chromosome
dc.description.departmentBiological Sciences
dc.description.advisorKelly Dyer
dc.description.committeeKelly Dyer
dc.description.committeeDaniel E.l. Promislow

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record