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dc.contributor.authorSmith, Maren
dc.date.accessioned2014-03-04T18:25:35Z
dc.date.available2014-03-04T18:25:35Z
dc.date.issued2009-12
dc.identifier.othersmith_maren_200912_bs
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/smith_maren_200912_bs
dc.identifier.urihttp://hdl.handle.net/10724/26157
dc.description.abstractThe Y chromosome is a non-recombining, patrilineal chromosome that is comprised of a few male specific genes, repetitive sequences, and transposable elements (Graves 2006). It is well known for its role in sex determination and male fertility, but recent research revealed a new activity for the Y chromosome: control of gene expression on other chromosomes in the genome. In 2008 Benardo Lemos discovered that, in Drosophila melanogaster, polymorphisms on the Y chromosome have differential effects on expression of autosomal and X-linked genes. Many of these genes are involved in pathways related to cellular stability and repair, which are mechanisms that have a role in the aging process. This led to the hypothesis that the Y chromosome may have an influence on aging. To study this possibility we created an isogenic line of D. melanogaster, and introduced eighteen Y chromosomes to this line: nine from African populations and nine from North American populations. We measured senescence in these flies by monitoring death rate over a 60 day period. We found significant variation in rate of aging in both male and female flies, hinting at the complex nature of studies of the aging process.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectSenescence, Y chromosome, Drosophila melanogaster, aging
dc.titleSenescence and the Y chromosome
dc.typeHonors
dc.description.degreeBS
dc.description.departmentBiological Sciences
dc.description.majorBiology
dc.description.advisorKelly Dyer
dc.description.committeeKelly Dyer
dc.description.committeeDaniel E.l. Promislow


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