Transmissibility and host predilection of epidemic vesicular stomatitis New Jersey virus strains
Smith, Paul Francis
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Epidemiologic data collected during epidemics in the western United States combined with limited experimental studies involving swine and cattle suggest that host predilection of epidemic Vesicular stomatitis New Jersey virus (VSNJV) strains result in variations in clinical response, extent and duration of virus shedding and transmissibility following infection in different hosts. Laboratory challenge of livestock with heterologous VSNJV strains to investigate a potential viral predilection for these hosts has not been thoroughly investigated. In this study, cattle, horses, and swine were inoculated various strains of VSNJV to investigated strain differences in clinical presentation and transmissibility following infection. Viral host predilections were demonstrated in cattle, but were less apparent in swine and horses. Biological transmission of VSNJV from an insect vector to multiple livestock hosts was demonstrated. In addition, transmission of VSNJV from livestock hosts to insect vectors in the absence of viremia was demonstrated as well. Animal-to-animal contact transmission of VSNJV was demonstrated in cattle an d horses. VSNJV epidemiology is discussed.