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    The effects of Staphylococcal enterotoxin B on equine T cells

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    Date
    2009-12
    Author
    Bauer, Liesel F.
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    Abstract
    Staphylococcus aureus enterotoxins and their impact on T cells in humans and mice are well described. S. aureus prevalence has not only increased in veterinary clinics, but is a relatively common isolate in horses, more so than in other animal species. Yet the role of superantigens in infection is unknown. With this in mind, the effects of staphylococcal enterotoxin B (SEB) on equine T cells were examined. Using an in vitro assay, dose responses and the kinetics of equine T cell proliferation were determined. Equine MHC class II was found to be important for SEB-mediated equine T cell stimulation. Using RT-PCR, the presence of SEB induced cytokine production (i.e. IFN-γ and IL-10) in equine T cells, but additional studies are needed. Taken together, these data suggest that virulence factors such as SEB when expressed may alter the clinical disease associated with S. aureus infection in horses.
    URI
    http://purl.galileo.usg.edu/uga_etd/bauer_liesel_f_200912_ms
    http://hdl.handle.net/10724/26003
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