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dc.contributor.authorTurner, Martha Kathleen
dc.date.accessioned2014-03-04T18:20:49Z
dc.date.available2014-03-04T18:20:49Z
dc.date.issued2009-08
dc.identifier.otherturner_martha_k_200908_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/turner_martha_k_200908_ms
dc.identifier.urihttp://hdl.handle.net/10724/25966
dc.description.abstractAnthocyanins are thought to have antioxidant effects in the body. The effects of two anthocyanins, malvidin and peonidin, on activity of antioxidant enzymes, glutathione-S-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx), were examined in HT-29 human adenocarcinoma cells. Cells were treated with each anthocyanin or a combination of both at concentrations of 0, 5, and 10 µg/mL in study one and 0, 2.5 and 5 µg/mL in study two. While the data suggests that these anthocyanin concentrations may increase activity of each enzyme, effects were often anthocyanin and dose-dependent. A synergistic effect between malvidin and peonidin was observed. At 2.5 µg/mL, the anthocyanins did not individually increase enzyme activity, however, a combined dose of 2.5 µg/mL significantly increased activity, GR by 55%, GPx by 21%, and GST by 42%. This study demonstrated that malvidin and peonidin have the potential to increase antioxidant enzyme activity at 10 µg/mL and below.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectAnthocyanin
dc.subjectAntioxidant
dc.subjectGlutathione peroxidase
dc.subjectGlutathione reductase
dc.subjectGlutathione-S-transferase
dc.titleAnthocyanins increase antioxidant enzyme activity in HT-29 adenocarcinoma cells
dc.typeThesis
dc.description.degreeMS
dc.description.departmentFoods and Nutrition
dc.description.majorFoods and Nutrition
dc.description.advisorJoan Fischer
dc.description.committeeJoan Fischer
dc.description.committeeJames Hargrove
dc.description.committeeArthur Grider


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