A field investigation of surveillance tools for lymphatic filariasis in children from Leogane, Haiti
Donaldson, Rachel Anne
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Interrupting transmission of lymphatic filariasis is dependent on annual mass drug administration (MDA) to reduce the reservoir of microfilariae available to mosquitoes. Microfilaremia, antigen, and antibody tests are used to monitor infections, but following MDA, the predictive value of these tests declines. Field studies were carried out in high and low prevalence communities in Leogane, Haiti, to test the hypothesis that filarial antigen-induced interferon-γ production in children may represent a measure of exposure that could be used as a surveillance tool. Anti-Bm14 IgG4 antibody reactivity was 39.2% and 0.8% in high and low prevalence areas. B. pahangi antigen-induced interferon-γ production was 15.5% and 19.5% among anti-Bm14 IgG4 antibody negative children in the high and low prevalence communities. IgG1 reactivity to Bm33 and Bm14 correlated significantly with anti-Bm14 IgG4 in both settings. Based on these results, assessment of antifilarial IgG1, but not interferon-γ responses may be useful for post-MDA surveillance.