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dc.contributor.authorBurge, Jessica Lynn
dc.date.accessioned2014-03-04T18:18:20Z
dc.date.available2014-03-04T18:18:20Z
dc.date.issued2009-08
dc.identifier.otherburge_jessica_l_200908_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/burge_jessica_l_200908_ms
dc.identifier.urihttp://hdl.handle.net/10724/25753
dc.description.abstractThis study investigated the effect of high fructose intakes in the rat diet on serum glucose, insulin, triglycerides, and ghrelin over the course of four weeks. We also examined expression of the ghrelin receptor, GHSR-1α, in the rat arcuate nucleus. No significant differences were found in body weight, food intake, serum triglycerides, or ghrelin during the four week period. Serum glucose was consistently higher in the fructose-fed group opposed to the dextrose group and the difference was significant at week 1 (p=.047), week 2 (p=.009), and week 4 (p=.009) measures. Serum insulin levels were also consistently greater in the fructose-fed group, but were only significant on the week 2 measurement (p=.0515, one way ANOVA) indicating the development of insulin resistance within a week of fructose feeding. Ghrelin receptor expression in the arcuate nucleus was significantly greater in rats fed a dextrose diet, opposed to the fructose-fed group (p=.0262). This may indicate an alteration in ghrelin receptor expression with high fructose intakes.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectghrelin
dc.subjectfructose
dc.subjectghrelin receptor
dc.subjectGHSR-1α
dc.subjectreceptor expression
dc.titleThe effect of high fructose intakes in the rat diet on serum ghrelin and receptor expression in the arcuate nucleus
dc.typeThesis
dc.description.degreeMS
dc.description.departmentFoods and Nutrition
dc.description.majorFoods and Nutrition
dc.description.advisorSilvia Giraudo
dc.description.committeeSilvia Giraudo
dc.description.committeeJohn Wagner
dc.description.committeeGaylen Edwards


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