Cancer biomarker discovery
MetadataShow full item record
A biomarker is a detectable characteristic change resulting from a certain stimulus. The stimuli can be tumor growth, virus invasion, drug usage, etc. Biomarker discovery is essential for cancer diagnostics as well as treatment. Glycosylation is an important post-translational modification. Aberrant glycosylation has been hallmark of malignant transformation. Recently efforts have been made to correlate glycosylation pattern changes with cancer progression. In this review, we make an extensive study of possible mass spectrometry associated glycomics methods in finding cancer biomarkers in human serum. Established methods, such as glycoprotein enrichment, glycosylation site mapping, and glycan analysis are discussed and compared. New mass spectrometry methods, such as Ion Mobility Mass Spectrometry, Multiple Reaction Monitoring, Electron Transfer Dissociation are introduced.