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dc.contributor.authorTownsend, Brigitte E.
dc.date.accessioned2014-03-04T16:22:37Z
dc.date.available2014-03-04T16:22:37Z
dc.date.issued2008-12
dc.identifier.othertownsend_brigitte_e_200812_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/townsend_brigitte_e_200812_ms
dc.identifier.urihttp://hdl.handle.net/10724/25337
dc.description.abstractPharmaceutical science has benefited from the variety of bioactive lead compounds discovered in marine organisms over the past several decades. The remarkable structural diversity of marine secondary metabolites brings marine natural product chemistry to the forefront of drug discovery. In search of novel therapeutic interventions, marine natural products research has converged with antioxidant studies to form an exciting new research focus. Phenolic antioxidants and indole alkaloids are among the most bioactive classes of marine metabolite, but relatively little has been done to thoroughly investigate the biomedical potential of organisms containing these types of metabolites. In this study, several compounds representing both of these structural classes were identified in marine sponges collected from the Western Atlantic. Several of the compounds were found to have high antioxidant potential when screened with the ferric-reducing antioxidant power (FRAP) assay. Antioxidant activity of marine samples was detected primarily in shallow and intermediate-water sponges, but no correlation was found between activity and fraction polarity.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectmarine natural products
dc.subjectantioxidants
dc.subjectFRAP assay
dc.subjectSmenospongia sp.
dc.subjectchromazonoral
dc.subjectbrominated aplysinopsins
dc.titleIdentification of marine antioxidants
dc.typeThesis
dc.description.degreeMS
dc.description.departmentPharmaceutical and Biomedical Sciences
dc.description.majorPharmacy
dc.description.advisorLyndon West
dc.description.committeeLyndon West
dc.description.committeeTimothy West
dc.description.committeePhillip Greenspan


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