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dc.contributor.authorXu, Meng
dc.date.accessioned2014-03-04T16:20:00Z
dc.date.available2014-03-04T16:20:00Z
dc.date.issued2008-08
dc.identifier.otherxu_meng_200808_phd
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/xu_meng_200808_phd
dc.identifier.urihttp://hdl.handle.net/10724/25093
dc.description.abstractAntiviral drugs are used therapeutically in pregnancy for treatment of both mother and fetus. Antiviral drugs are presumed to prevent viral transmission from mother to fetus by decreasing maternal viral load and/or accumulation of the drugs in the fetal compartment. Due to a number of reasons, pregnant women are generally not used during clinical trials, so very little is known about the behavior of therapeutic agents during pregnancy. A pregnant rat model has been developed to investigate the pharmacokinetics and placental transport of antivirals during pregnancy. Presented here are validated analytical methods for the extraction and quantitation of the nucleoside reverse transcriptase inhibitors zalcitabine (DDC) and stavudine (D4T) in the various matrices needed to support the maternal-fetal pharmacokinetic studies. Also presented here are the pharmacokinetics of DDC and D4T, using the pregnant rat model.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectAnalytical
dc.subjectPharmacokinetics
dc.subjectHIV
dc.subjectZalcitabine
dc.subjectDDC
dc.subjectStavudine
dc.subjectD4T
dc.subjectLamivudine
dc.subject3TC
dc.subjectplacental transport
dc.subjectfetal disposition
dc.titleQuantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat
dc.typeDissertation
dc.description.degreePhD
dc.description.departmentPharmaceutical and Biomedical Sciences
dc.description.majorPharmacy
dc.description.advisorMichael G. Bartlett
dc.description.committeeMichael G. Bartlett
dc.description.committeeRandall L. Tackett
dc.description.committeeJ. Warren Beach
dc.description.committeeJames V. Bruckner
dc.description.committeeCatherine A. White


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