Nanog modification and degradation in murine embryonic stem cells
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Embryonic stem cells are pluripotent progenitors for virtually all cell types in our body and contain limitless potential for therapeutic use and regenerative medicine. Murine embryonic stem cells can be maintained as a self-renewing, pluripotent population by LIF/STAT3-dependent signaling, and are regulated by a combination of extrinsic and intrinsic factors. The nuclear transcription factor, Nanog, plays a key role in maintaining these stem cell properties. However, little is known about the regulation of Nanog or its degradation during differentiation. This research is focused on elucidating the possible relationship between Nanog and other factors that could play a role in Nanog degradation.