Detection and classification of measles virus by surface-enhanced Raman scattering (SERS) spectroscopy and Fourier transform infrared (FTR) spectroscopy
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Measles is a disease most prevalent in young children. The acute infection occurs once in a lifetime, and immunity is attained. Nonetheless, measles can thrive in large susceptible populations, and continue to contribute to the high mortality rate in underdeveloped countries. Currently, diagnosis methods for measles include immunofluorescent antibody assays and enzyme-linked immunoassays (ELISAs). However, these current assays are time-consuming and do not allow for direct analysis of the virus. Unlike the current immunoassays, the high sensitivity of surface-enhanced Raman scattering (SERS) spectroscopy allows for direct and rapid measles detection at low concentration and with minimal sample preparation. Thus, SERS could be the potential diagnostic tool for measles detection. The second method for measles detection was Fourier transform infrared (FTIR) spectroscopy. Rapid detection of pathogens was made possible by FTIR spectroscopy because of the minimal sample preparation and short data collection time.