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dc.contributor.authorGregg, Laura
dc.date.accessioned2014-03-04T03:19:52Z
dc.date.available2014-03-04T03:19:52Z
dc.date.issued2008-05
dc.identifier.othergregg_laura_200805_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/gregg_laura_200805_ms
dc.identifier.urihttp://hdl.handle.net/10724/24617
dc.description.abstractStress-induced analgesia (SIA) is mediated by mobilization of endocannabinoid lipids such as 2-arachidonoylglycerol (2-AG) in the midbrain periaqueductal gray (PAG). 2-AG may be synthesized on demand to induce SIA through the consecutive activation of two enzymes- phospholipase C (PLC) and diacylglycerol lipase (DGL). We examined whether activation of postsynaptic group I metabotropic glutamate receptors (mGluRs) would enhance SIA because of their known coupling to PLC. Microinjection of the group I mGluR agonist DHPG into the dorsolateral PAG (dPAG) enhanced SIA through a CB1-dependent mechanism. Microinjection of the DGL inhibitors tetrahydrolipstatin (THL) and RHC80267 into the dPAG suppressed SIA. The DHPG-induced enhancement of SIA was blocked by THL. Off-site injections of the active compounds did not alter SIA. Our results support the hypothesis that exposure to environmental stressors stimulates synthesis of 2-AG through the PLC/DGL pathway to induce SIA. Moreover, this process may be initiated by activation of group I mGluRs.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectendocannabinoid
dc.subjectantinociception
dc.subjectmetabotropic glutamate receptors
dc.titleGroup I metabotropic glutamate receptors modulate endocannabinoid-mediated stress-induced analgesia
dc.typeThesis
dc.description.degreeMS
dc.description.departmentPsychology
dc.description.majorPsychology
dc.description.advisorAndrea G. Hohmann
dc.description.committeeAndrea G. Hohmann
dc.description.committeePhilip V. Holmes
dc.description.committeeJonathon D. Crystal


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