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dc.contributor.authorDiyunugala, Tharanga Indika
dc.date.accessioned2014-03-04T03:19:22Z
dc.date.available2014-03-04T03:19:22Z
dc.date.issued2008-05
dc.identifier.otherdiyunugala_tharanga_i_200805_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/diyunugala_tharanga_i_200805_ms
dc.identifier.urihttp://hdl.handle.net/10724/24594
dc.description.abstractFree radicals and reactive oxygen species can have adverse affects on human health. Many pathological conditions including cancer are related to free radical mediated cellular damage. Antioxidant molecules and enzymes in the body act as a defense system against the potential toxicity of these harmful molecules. Superoxide dismutases are special metallo-enzymes that protect cells from deleterious superoxide anion radical by a catalytic disproportionating mechanism. Four classes of superoxide dismutases based on the active site metal are known to date. A novel nickel containing superoxide dismutase has been characterized recently. The chemistry, enzymatic function, and the future perspective of this enzyme as a therapeutic agent in curing diseases are reviewed in this thesis.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectFree radicals
dc.subjectsuperoxide anion radical
dc.subjectantioxidants
dc.subjectoxidative stress
dc.subjectsuperoxide dismutase
dc.subjectSOD therapy
dc.titleSuperoxide dismutase
dc.title.alternativean emphasis on nickel superoxide dismutase chemistry and future perspectives
dc.typeThesis
dc.description.degreeMS
dc.description.departmentChemistry
dc.description.majorChemistry
dc.description.advisorTodd Harrop
dc.description.committeeTodd Harrop
dc.description.committeeJohn Stickney
dc.description.committeeGeoffrey Smith


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