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dc.contributor.authorVaughn, Lara Elizabeth
dc.date.accessioned2014-03-04T02:53:12Z
dc.date.available2014-03-04T02:53:12Z
dc.date.issued2007-12
dc.identifier.othervaughn_lara_e_200712_phd
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/vaughn_lara_e_200712_phd
dc.identifier.urihttp://hdl.handle.net/10724/24519
dc.description.abstractThe crop (ingluvies) of the chicken (Gallus gallus) is an anatomical diverticulum of the esophagus and is regarded as a food storage organ. Additionally, the crop may function as a component of the extensive mucosal immune system of the gastrointestinal tract. Following experimental per os (oral) challenge with Salmonella enterica serovar Enteritidis (SE), a SE-lipopolysaccharide (LPS)-specific IgA humoral immune response was detected within the crop and a recall response to SE antigen was generated after SE re-infection. Increased lymphoid tissue was observed within the crop lamina propria of SE-infected chickens compared to uninfected controls. B-lymphocytes and plasma cells were identified within isolated lymphoid follicles (ILF), thus cellular populations exist that have the capacity to generate a humoral response locally within the crop. Commercial egg-layer hen strains and specific pathogen free (SPF) White Leghorn (WL) chickens presented similar findings of an increased SE-LPS-specific IgA response and lymphoid tissue presence within the crop organ post-SE infection. Bacteriological assessment of crop lavage samples revealed viable SE harbored within the crop and that SE persisted within the organ for extended time. The crop may be a potential reservoir for spread of SE in flock and/or a potential source of SE contamination to poultry carcasses during processing. The chicken crop deserves more attention as part of the integrated mucosal immune system and as an organ of importance in SE pathogenesis.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectchicken
dc.subjectcrop
dc.subjectingluvies
dc.subjectSalmonella Enteritidis
dc.subjectmucosal immune system
dc.subjectgut-associated lymphoid tissue
dc.subjectisolated lymphoid follicles
dc.subjectimmunohistochemistry
dc.subjectenzyme-linked immunosorbent assay
dc.subjectimmunoglobulin-A
dc.subjecthumoral response
dc.titleEvaluation of the possible immunological function of the chicken crop (ingluvies)
dc.typeDissertation
dc.description.degreePhD
dc.description.departmentInfectious Diseases
dc.description.majorMedical Microbiology
dc.description.advisorMark Jackwood
dc.description.committeeMark Jackwood
dc.description.committeeLiliana Jaso-Friedmann
dc.description.committeeDavid Stallknecht
dc.description.committeeCorrie Brown
dc.description.committeePeter Holt


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