Replication, transmission, and protection of live-attenuated infectious laryngotracheitis virus (ILTV) vaccines
Avila, Andres Rodriguez
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Infectious laringotracheitis virus (ILTV) is associated with serious economic losses due to clinical signs, mortality, decreased egg production, and predisposition to other avian pathogens. The virus is a member of family herpesviridae, subfamily Alphaherpesvirinae, and it is taxonomically classified as Gallid herpesvirus 1. Although it was the first poultry pathogen controlled by vaccination, ILTV is still a major problem in areas where dense bird populations exist. Currently, there are two main types of ILTV live vaccines commercially available, those attenuated by sequential passages in chicken embryos (CEO) or by sequential passages in tissue culture (TCO). The replication, transmission, and protection of the CEO and TCO vaccines were evaluated using vaccinated, contact-exposed, and sentinel specific pathogen free chickens. No differences were observed in the ability of the CEO and TCO vaccines to replicate in the upper respiratory tract, to transmit to contact-exposed birds, and to induce protection against the challenge virus. However, chickens contact-exposed to vaccinates were not protected against challenge.