The immunopathogenesis of canine ocular nodular episcleritis
Williams, Clara Orozco
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Canine ocular nodular episcleritis (CONE) or nodular granulomatous episcleritis develops in the sclera, limboscleral junction and third eyelid and may infiltrate the cornea and its etiology is unknown. This condition is recurrent and inconsistently responds to surgery and immunomodulating medications. We characterized CONE histologically and for the first time immunohistochemically. Forty-two paraffin-embedded specimens obtained from UGA and COPLOW laboratories were stained with H&E and characterized histologically as inflammatory or proliferative. Tissues were stained with Masson’s trichrome, Reticulin, CD3, CD79, MAC387, TGFß2, smooth muscle actin (SMA), and desmin. Twenty-three samples (54.5%) were characterized as inflammatory (predominant CD3+ and SMA) and 17(46.5%) as proliferative (predominant TGFß2 and reticulin). CD3+ and TGFß2 were predominant in both groups. The histiocytic-like cells seen in both lesions were non-immunoreactive for MAC387, those cells may be histiocytes in a different stage not expressing MAC387 or may cells from a different lineage.