The effects of chronic activity-wheel running on copulatory behavior and galanin mRNA in the medial preoptic area and locus coeruleus of male rats after [beta]-adrenoreceptor blockade
Thom, Nathaniel John
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The experiment investigated whether three weeks of activity-wheel running would increase male copulation and galanin (GAL) mRNA in the medial preoptic area (MPOA) and locus coeruleus (LC) after -adrenoreceptor blockade with propranolol administered chronically into the third ventricle of the brain. Contrary to expectations, animals treated with saline had abnormally low rates of intromission and ejaculation compared to home cage (HC) controls and lower GAL mRNA in the MPOA compared with propranolol and HC groups, which did not differ. Propranolol normalized GAL mRNA levels in the MPOA compared to saline treated animals and induced copulatory decrements compared to HC. Wheel running mitigated the copulatory decrement after propranolol treatment but did not increase GAL mRNA in the MPOA. These results are consistent with noradrenergic adaptations in the MPOA after wheel running that facilitate male copulation independently of gene expression of GAL in the MPOA or LC.