Comparative genomics visualization
MetadataShow full item record
As an increasing number of genomes are sequenced, comparative genomics analysis at different evolutionary distances plays a crucial role in decoding genomic information and discovering the similarities and differences between the genomes. It consists of three process steps: data preparation, sequence alignment, and visualization. In this thesis the major alignment methods and visualization tools are discussed. Based on an analysis of current work, we have designed and implemented a comparison visualization approach that satisfies the specific requirements of the CryptoDB project (http://cryptodb.org) (45). Our approach is written in Perl and based on the GBrowse framework. In addition, this study also presents an analysis of the comparison of C. hominis and C. parvum to find candidate insertions, deletions, and synteny blocks. Future work is also discussed.