Show simple item record

dc.contributor.authorBolt, Kari Elizabeth
dc.description.abstractThis study investigated the levels of mRNA of POMC, AgRP and MC4R in the arcuate nucleus and paraventricular nucleus of the hypothalamus in thirty Sprague Dawley rats fed a low fat diet or a high fat diet over the course of 12 weeks. The HF group had higher levels of POMC (p=0.013) and AgRP (p=0.001) in the ARC after 7 weeks of feeding. The HF group did have higher levels of MC4R (p=0.038) in the PVN after 12 weeks of feeding. POMC and AgRP mRNA expression in the ARC seemed to increase and decrease in a similar pattern during high fat feeding, while the varying levels of MC4R mRNA expression in the PVN seems to be inversely related to AgRP and POMC expression in the ARC. This may indicate a link in regulation or a breakdown energy balance that supports a state positive energy balance.
dc.subjectMelanocortin System
dc.subjectPOMC mRNA
dc.subjectAgRP mRNA
dc.subjectMC4R mRNA
dc.subjectHigh fat diet
dc.subjectDiet-induced obesity
dc.subjectEnergy balance
dc.subjectSprague Dawley
dc.subjectGene expression
dc.titleEffects of a high fat diet on POMC, AgRPand MC4R gene expression in the arcuate nucleus and paraventricular nucleus of the hypothalamus
dc.description.departmentFoods and Nutrition
dc.description.majorFoods and Nutrition
dc.description.advisorSilvia Giraudo
dc.description.committeeSilvia Giraudo
dc.description.committeeRuth Harris
dc.description.committeeRichard Lewis

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record