• Login
    View Item 
    •   Athenaeum Home
    • University of Georgia Theses and Dissertations
    • University of Georgia Theses and Dissertations
    • View Item
    •   Athenaeum Home
    • University of Georgia Theses and Dissertations
    • University of Georgia Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The effects of body fat and fitness on vascular health

    Thumbnail
    Date
    2005-08
    Author
    Sabatier, Manning Joseph
    Metadata
    Show full item record
    Abstract
    It is currently unclear whether the negative effect of body fat on vascular health is due to low aerobic fitness. It is also unclear whether a decrease in body fat mediates improvements in vascular health that occur with aerobic exercise. The purposes of the following studies were to 1) evaluate the relationships of adiposity (percent body fat determined by dual energy x-ray absorptiometry) and aerobic fitness (VO2peak normalized to fat-free mass) with vascular health (i.e., systemic and vascular inflammation, leptin, central arterial stiffness; and femoral artery diameter (DFA), blood flow (BFFA), and shear rate), 2) evaluate the relationship of leg fat and fat-free mass (FFM) with DFA and BFFA, and 3) determine whether the effect of aerobic exercise training on vascular health is dependent on a reduction in adiposity. Forty-six pre-menopausal women (25-40 years old) were recruited for the cross-sectional study. C-reactive protein (CRP) was a significantly correlated with adiposity, but not VO2peak (R=0.46, P=0.002). VO2peak reduced the increase in CRP associated with an increase in % body fat (interaction effect, P=0.01). Leptin was correlated with adiposity (R=0.77, P<0.001), as well as CRP (r=0.36, P=0.01) and ICAM-1 (r=0.56, P<0.001). Aortic pulse wave velocity (aPWV) was significantly correlated with VO2peak, but not adiposity, (R=-0.42, P=0.02). DFA was significantly correlated with VO2peak (R=0.42, P=0.004). DFA and BFFA were correlated with leg FFM (r=0.28, P=0.03; r=0.26, P=0.06). For the exercise training study, thirteen sedentary women (33±4 yrs) were tested before and after 14 weeks of cycle exercise. aPWV and sICAM-1 did not change with training, whereas CRP was reduced by 35% (P=0.05). Leptin also decreased 20% (P=0.04). Resting DFA increased 11.7% (P<0.001) and shear rate decreased 28% (P=0.007). Taken together, these studies provide evidence that increased aerobic fitness is positively associated with, or positively affects, each of these measures. The results of these studies support the concept that aerobic fitness modifies the negative effect that body fat may have on vascular health.
    URI
    http://purl.galileo.usg.edu/uga_etd/sabatier_manning_j_200508_phd
    http://hdl.handle.net/10724/22780
    Collections
    • University of Georgia Theses and Dissertations

    About Athenaeum | Contact Us | Send Feedback
     

     

    Browse

    All of AthenaeumCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    About Athenaeum | Contact Us | Send Feedback