Insulin-like growth factors and bone in young female gymnasts
Gildea, Ruth Ann
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The effects of 24-months of recreational artistic gymnastics participation on plasma insulin-likegrowth factor-I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3) and bone wereassessed in prepubertal females, four to eight years of age, with no history of sports participation.Over 24-months, log IGF-I, IGFBP-3 and IGF-I/IGFBP-3 increased in gymnasts (n=48) andcontrols (n=66). When gymnasts and controls were combined, the 24-month log IGF-I and totalbody bone area, bone mineral content (BMC) and areal bone mineral density (aBMD), lumbarspine BMC and aBMD, femur BMC and aBMD, narrow neck cross sectional area (CSA),intertrochanteric CSA and section modulus (Z) and shaft Z were correlated. Negativecorrelations were observed between hours of gymnastics participation and the 24-month gain inlog IGF-I, IGFBP-3 and IGF-I/IFGBP-3. The lack of a marked IGF response and the small boneresponse to participation in recreational artistic gymnastics in the current project may be partiallyrelated to the young age of participants.