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dc.contributor.authorThomas, Stuart Dudley
dc.date.accessioned2014-03-03T23:16:23Z
dc.date.available2014-03-03T23:16:23Z
dc.date.issued2005-05
dc.identifier.otherthomas_stuart_d_200505_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/thomas_stuart_d_200505_ms
dc.identifier.urihttp://hdl.handle.net/10724/22530
dc.description.abstractEcdysteroidogenesis, ecdysteroid titer of hemolymph and yolk deposition over the course of a gonotrophic cycle are quantified for the first time for female Anopheles gambiae. The trend of ecdysteroid secretion roughly matched that of Aedes aegypti. A cDNA sequence for an ovary ecdysteroidogenic hormone (AgamOEH) in Anopheles gambiae was also characterized. This peptide also showed similarity to the Ae. aegypti OEH in amino acid sequence. The distribution of the AgamOEH transcript and peptide are also described for An. gambiae at different life stages and during a gonotrophic cycle. We partially purified a putative OEH peptide from 20,800 adult An. gambiae heads with multiple HPLC runs. Finally, we were unable to prove bioactivity of the purified peptide but were able to demonstrate the ability of bovine insulin to activate oocyte development in vivo.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectAnopheles gambiae
dc.subjectecdysteroids
dc.subjectovary ecdysteroidogenic hormone
dc.titleCharacterization of the ovary ecdysteroidogenic hormone and ovarian ecdysteroidogenesis in the African malaria mosquito, Anopheles gambiae
dc.typeThesis
dc.description.degreeMS
dc.description.departmentEntomology
dc.description.majorEntomology
dc.description.advisorMark R. Brown
dc.description.committeeMark R. Brown
dc.description.committeeDonald Champagne
dc.description.committeeNancy Hinkle


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