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dc.contributor.authorPoulos, Sylvia Pete
dc.date.accessioned2014-03-03T23:15:24Z
dc.date.available2014-03-03T23:15:24Z
dc.date.issued2005-05
dc.identifier.otherpoulos_sylvia_p_200505_phd
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/poulos_sylvia_p_200505_phd
dc.identifier.urihttp://hdl.handle.net/10724/22480
dc.description.abstractThe forthcoming pandemic of obesity and type 2 diabetes mellitus has stimulated muchresearch aimed at understanding the regulation of energy balance and adipose tissue growth. Intramuscular lipid accumulation has recently been highly correlated to insulin resistance, suggesting this lipid plays a key role in regulating energy homeostasis in skeletal muscle. It isknown that muscle type, age, gender, exercise, diet, and disease status all play a role inintramuscular lipid accumulation. However, little is known about the development of adiposetissue within skeletal muscle, known as intramuscular adipogenesis. Thus the aim of thesestudies was to compare intramuscular adipogenesis to subcutaneous adipogenesis in both in vitroand in vivo studies. Thiazolidinediones, a class of pharmaceuticals currently used in thetreatment of type 2 diabetes mellitus, are known adipogenic agents and were used in thesestudies. Our results suggest intramuscular adipogenesis is regulated in a manner different thansubcutaneous adipogenesis. Differential regulation of these two depots may provide treatmentoptions for obese and diabetic patients and may be useful in animal production as well. However, further research into the growth and development of intramuscular adipose tissue iswarranted.
dc.languageeng
dc.publisheruga
dc.rightsOn Campus Only
dc.subjectthiazolidinedione
dc.subjectadipogenesis
dc.subjectskeletal muscle
dc.subjectadipose tissue
dc.subjectadipogenesis
dc.subjectco-culture
dc.subjectporcine
dc.titleThiazolidinedione induced adipogenesis in porcine subcutaneous and intramuscular adipose tissue depots
dc.typeDissertation
dc.description.degreePhD
dc.description.departmentFoods and Nutrition
dc.description.majorFoods and Nutrition
dc.description.advisorGary J. Hausman
dc.description.committeeGary J. Hausman
dc.description.committeeMichael J. Azain
dc.description.committeeJoan Fischer
dc.description.committeeArthur Grider
dc.description.committeeRuth B. S. Harris


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