Thiazolidinedione induced adipogenesis in porcine subcutaneous and intramuscular adipose tissue depots
Poulos, Sylvia Pete
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The forthcoming pandemic of obesity and type 2 diabetes mellitus has stimulated muchresearch aimed at understanding the regulation of energy balance and adipose tissue growth. Intramuscular lipid accumulation has recently been highly correlated to insulin resistance, suggesting this lipid plays a key role in regulating energy homeostasis in skeletal muscle. It isknown that muscle type, age, gender, exercise, diet, and disease status all play a role inintramuscular lipid accumulation. However, little is known about the development of adiposetissue within skeletal muscle, known as intramuscular adipogenesis. Thus the aim of thesestudies was to compare intramuscular adipogenesis to subcutaneous adipogenesis in both in vitroand in vivo studies. Thiazolidinediones, a class of pharmaceuticals currently used in thetreatment of type 2 diabetes mellitus, are known adipogenic agents and were used in thesestudies. Our results suggest intramuscular adipogenesis is regulated in a manner different thansubcutaneous adipogenesis. Differential regulation of these two depots may provide treatmentoptions for obese and diabetic patients and may be useful in animal production as well. However, further research into the growth and development of intramuscular adipose tissue iswarranted.