Synthesis and characterization of artificial lipoprotein for targeted drug delivery ; influence of formulation factors on the drug release kinetics of whole and half controlled-release trazodone HCL tablets
Adams, Tiffany S
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Part I. Low-density lipoprotein, LDL, are natural plasma components that have been investigated as advanced drug delivery systems to overcome the limitations of conventional drug delivery systems. LDL transport cholesterol throughout the body and delivers it to cells via receptor-mediated endocytosis. Several cancer cells have been reported to express elevated levels of LDL receptors as well as other types of receptors. Therefore, artificial lipoprotein have been identified as potential drug delivery systems for anticancer agents with hopes of selectively targeting these agents to cancer cells via elevated LDL receptors or other elevated receptors. The artificial lipoprotein is composed of an oil-in-water emulsion core and a chemically modified surface protein. Part II. Controlled-release dosage forms offer several advantages compared to conventional dosing methods. The objectives of this research were 1) to develop a controlled- release tablet containing trazodone HCL, 2) to evaluate the effect of formulation factors on the release rate of trazodone HCL, and 3) to study the dissolution characteristics of whole and halfcontrolled-release trazodone HCL tablets. In vitro studies revealed that polymer type and drug to polymer ratios influenced the rate of drug release. The half tablets had significantly higher release rates compared to the whole tablets.