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dc.contributor.authorRogers, Emily Dawn
dc.date.accessioned2014-03-03T21:26:22Z
dc.date.available2014-03-03T21:26:22Z
dc.date.issued2004-08
dc.identifier.otherrogers_emily_d_200408_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/rogers_emily_d_200408_ms
dc.identifier.urihttp://hdl.handle.net/10724/21957
dc.description.abstractFluoxetine, a widely prescribed antidepressant, has been detected at low concentrations (ppt - ppb) in surface water. Mammalian studies indicate that fluoxetine may inhibit the thyroid axis. In larval frogs, increasing levels of thyroid hormones are necessary for metamorphosis to occur, and the presence of fluoxetine in aquatic habitats may have the potential to decrease thyroid hormone levels and delay the completion of metamorphosis. To test this hypothesis, we exposed Xenopus laevis embryos to fluoxetine until the completion of metamorphosis. Metamorphosis was significantly delayed at 50 ppb, a concentration that would not be expected to occur in the environment. Effects at environmentally relevant concentrations included significant reductions in size at metamorphosis, as well as limb malformations. Because decreased survival and reproductive success have been associated with malformations and reduced size at metamorphosis, our findings suggest that the presence of low levels of fluoxetine in aquatic habitats may adversely affect amphibian populations.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectpharmaceutical
dc.subjectfluoxetine
dc.subjectXenopus laevis
dc.subjectamphibian
dc.subjectmalformation
dc.subjectammonium perchlorate
dc.titleEffects of fluoxetine on development and metamorphosis of the African clawed frog, Xenopus laevis
dc.typeThesis
dc.description.degreeMS
dc.description.departmentEnvironmental Health Science
dc.description.majorToxicology
dc.description.advisorMarsha C. Black
dc.description.committeeMarsha C. Black
dc.description.committeeAaron T. Fisk
dc.description.committeeWilliam A. Hopkins
dc.description.committeeCharles H. Jagoe


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