Chronic versus acute NMDA receptor antagonism in the ventral striatum
Guth, Amanda Nicole
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Bilateral ablation of the olfactory bulbs results in a depressive- like behavioral syndrome characterized by deficits in appetitively motivated behaviors and a hyperactive response to stress. Bulbectomy disrupts both ascending monoaminergic and descending glutamatergic pathways; however, it is not known which pathway is involved in the manifestation of the hallmark feature of the olfactory bulbectomy syndrome, a hyperactive stress response. To determine if disruption of glutamatergic signaling in the ventral striatum, a major target of the olfactory bulbs, is responsible for the hyperactive stress response seen following bulbectomy, NMDA receptors in this regions were acutely and chronically blocked with the competitive antagonist AP-5. Chronic, but not acute, NMDA receptor antagonism resulted in open field hyperactivity, as indicated by increased locomotor and stereotypic behavior. The results of the current experiments suggest that disruption of glutamatergic signaling, at NMDA receptors, is, in part responsible for the hyperactive stress response seen following bulbectomy.