Determination of partition coefficients for selected n-alkanes and other key constituents of JP-8
Smith, Andrew Quin
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JP-8, the primary aviation fuel source used by the U.S. and NATO forces, is comprised of a complex mixture of aliphatic and aromatic hydrocarbons. Exposure occurs primarily via inhalation and dermal contact. A complex mixture PBPK model for JP-8 is in development to aid in understanding target tissue dosimetry. N-alkanes, n-octane through n-dodecane (C8-C12) comprise a large majority of neat JP-8 (by weight). As part of model development efforts, tissue:air and blood:air partition coefficients for C8-C12 n-alkanes, and other key constituents of JP-8 were determined. Rat tissue:air partition coefficients for liver, muscle, brain, fat, and whole blood were determined using the vial equilibration method modified by Gargas et al. (1989). The results indicate increasing partitioning into tissues with increasing carbon chain length of n-alkanes. These reported tissue solubility results represent an important step in the future development of a PBPK model for JP-8.