A physiologically based pharmacokinetic model for decane
Perleberg, Ulrich Reiko
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Decane, a 10-carbon n-alkane, was selected to represent the semi-volatile fraction for the initial development of a physiologically-based pharmacokinetic (PBPK) model for Jet Propellant-8. Rats were exposed to decane vapors at time weighted average concentrations of 1200, 781, or 273ppm in a 32L leach chamber for 4hrs. Time course samples for 1200ppm and end of exposure samples for 781 and 273ppm decane exposures were collected from blood, brain, liver, fat, bone marrow, lung, skin, and spleen. A PBPK model for decane was developed using flow-limited and diffusion-limited equations to describe the uptake and clearance of decane in the blood and tissues. Model predictions were adequate in most tissues and blood. For model validation, the model had mixed successes at predicting tissue and blood concentrations for lower concentrations of decane vapor, suggesting that further improvements in the model may be necessary for extrapolating to concentrations less than 100ppm.