Show simple item record

dc.contributor.authorMcGraw, Sabrina Nicole
dc.date.accessioned2014-03-03T21:18:57Z
dc.date.available2014-03-03T21:18:57Z
dc.date.issued2004-05
dc.identifier.othermcgraw_sabrina_n_200405_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/mcgraw_sabrina_n_200405_ms
dc.identifier.urihttp://hdl.handle.net/10724/21585
dc.description.abstractPrimary granule cell degeneration (PGD) is an autosomal recessive cerebellar ataxia that has been described in Jack Russell Terriers. This ataxia differs from existing mouse models and most other ataxias in that it has a very early onset and it exhibits primary granule cell loss rather than Purkinje involvement. Homozygosity mapping was used to analyze the canine genome of a small panel of affected animals. This screen included 496 markers, of which 377 were ruled unlikely to be linked to the defective locus. An unexpected level of homozygous and otherwise uninformative markers was seen in this screen, attributable to the close relationship between the animals studied. We were able to rule out 24 of the 38 autosomal chromosomes, leaving 16 possible regions containing the defective locus. Within these regions are 12 relevant genes suggested for further study.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectcerebellum
dc.subjectataxia
dc.subjectJack Russell Terrier
dc.subjectgranule cell
dc.subjectapoptosis
dc.subjecthomozygosity mapping
dc.subjectPGD
dc.subjectprimary granule cell degeneration
dc.titleLocalization of the genetic defect in a canine cerebellar ataxia
dc.typeThesis
dc.description.degreeMS
dc.description.departmentPhysiology
dc.description.majorPhysiology
dc.description.advisorRoyal A McGraw
dc.description.committeeRoyal A McGraw
dc.description.committeeK Paige Carmichael
dc.description.committeeThomas Murray


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record