Equine ocular squamous cell carcinoma : retrospective and diagnostic studies
Mosunic, Cory Baird
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Squamous cell carcinoma is the most prevalent tumor of the eye and adnexa in the horse. The first part of this study revealed retrospectively that ocular squamous cell carcinoma is most prevalent in chestnut, middle aged, Quarter Horse geldings at the University of Georgia. Post treatment recurrence versus non-recurrence was evaluated and radiation treatment at all tumor locations yielded a significantly lower recurrence rate when compared to non-radiation therapies. The second part of the study evaluated histopathological tools to assist in the diagnosis of borderline cases of squamous epithelial neoplasms that range from the benign squamous plaque through squamous cell carcinoma in situ and finally invasive squamous cell carcinoma. Our study revealed that AgNOR score is a proliferation assay that is able to distinguish between types of all ocular epithelial neoplasms in the horse. p53 immunoreactivity and Ki-67 proliferation assay are more limited in their ability to distinguish between equine epithelial neoplasms.