Investigations on four antibiotics for possible use against E. coli in broiler chickens
Manning, Kristi Lind
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Four antibiotics (enrofloxacin, sulfaquinoxaline, sulfadimethoxine, and sulfamethazine) were tested using the tube dilution method to determine the minimum inhibitory concentration (MIC) of each antibiotic against E. coli isolated from poultry. Enrofloxacin was the only antibiotic tested that had a maximum plasma level higher than the average MIC, which suggests the sulfonamides are inadequate to treat systemic E. coli infections in broiler chickens. Thombroelastography values for the reaction rate (R), coagulation time (K), clot formation rate (angle) and maximum amplitude (MA) were determined for blood from broiler chickens after receiving one of the antibiotics. The MA of the enrofloxacin-treated chickens was significantly lower than the MA of the control chickens, suggesting a decrease in thrombocytes or decreased fibrinogen concentration. The R and K were prolonged and the angle and MA were increased in the sulfaquinoxaline-treated chickens, suggesting that sulfaquinoxaline affects thrombin generation, fibrin formation, clotting factors and thrombocyte number and function.