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dc.contributor.authorCole, Russell David
dc.date.accessioned2014-03-03T20:29:03Z
dc.date.available2014-03-03T20:29:03Z
dc.date.issued2003-08
dc.identifier.othercole_russell_d_200308_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/cole_russell_d_200308_ms
dc.identifier.urihttp://hdl.handle.net/10724/21010
dc.description.abstractResearch has shown a number of basic similarities between the nervous systems of the nematode Caenorhabditis elegans and higher animals including mammals. The purpose of this study was to investigate the toxicity of a chemical class known to be neurotoxic in C. elegans and compare this toxicity to that seen in mammals. The behavioral response of C. elegans to 15 organophosphate (OP) pesticides was characterized using computer automated tracking. Toxicity was ranked and compared to the ranked toxicity of the same compounds in rats and mice. Toxic mechanism was also examined through cholinesterase activity assays performed on worms exposed to 8 of the 15 OPs. A significant correlation was found between rank order of toxicity in C. elegans and rats and mice. Cholinesterase inhibition by some OPs was also confirmed in C. elegans. Specific comparisons and implications concerning C. elegans’ potential as a mammalian neurotoxicity model are discussed.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectCaenorhabditis elegans
dc.subjectOrganophosphate
dc.subjectNeurotoxicity
dc.subjectRats
dc.subjectMice
dc.subjectBehavior
dc.subjectCholinesterase
dc.subjectBiological Model
dc.titleThe nematode Caenorhabditis elegans as a model of organophosphate induced mammalian neurotoxicity
dc.typeThesis
dc.description.degreeMS
dc.description.departmentEnvironmental Health Science
dc.description.majorToxicology
dc.description.advisorPhillip L. Williams
dc.description.committeePhillip L. Williams
dc.description.committeeCham E. Dallas
dc.description.committeeJeffrey W. Fisher


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