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dc.contributor.authorBrennan, Christina Leigh
dc.date.accessioned2014-03-03T20:23:27Z
dc.date.available2014-03-03T20:23:27Z
dc.date.issued2003-05
dc.identifier.otherbrennan_christina_l_200305_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/brennan_christina_l_200305_ms
dc.identifier.urihttp://hdl.handle.net/10724/20731
dc.description.abstractAs in man, obesity is a risk factor for many diseases including diabetes mellitus. The cat is an important and unique model for the study of obesity and its progression to diabetes. Recently, tissue specific regulation of glucose metabolism in fat and muscle has been identified as an important factor for insulin sensitivity and it has been hypothesized that glucose uptake into tissues is altered in obesity causing insulin resistance. Seventeen cats were tested in the lean state and again after a 6 month period of ad libitum food intake which led to a significant increase in weight (p < 0.0001). The Glut4 expression was significantly decreased in both muscle (p< 0.01) and adipose tissue (p<0.001), respectively, in the obese cats. Glut1 expression showed no significant change in the obese cats in either muscle or adipose tissue.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectObesity
dc.subjectDiabetes Mellitus
dc.subjectGlut1
dc.subjectGlut4
dc.subjectMuscle
dc.subjectAdipose tissue
dc.titleChanges in Glut4 and Glut1 in feline obesity
dc.typeThesis
dc.description.degreeMS
dc.description.departmentPhysiology and Pharmacology
dc.description.majorPharmacology
dc.description.advisorMargarethe Hoenig
dc.description.committeeMargarethe Hoenig
dc.description.committeeDuncan Ferguson
dc.description.committeeThomas Krunkosky


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