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dc.contributor.authorMusami, Patrick
dc.date.accessioned2014-03-03T20:21:18Z
dc.date.available2014-03-03T20:21:18Z
dc.date.issued2002-12
dc.identifier.othermusami_patrick_200212_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/musami_patrick_200212_ms
dc.identifier.urihttp://hdl.handle.net/10724/20632
dc.description.abstractThe stability of 10mg/mL zidovudine and either 12.5mg/mL dobutamine or 25 mg/L ranitidine hydrochloride stored in 0.9% sodium chloride and 5 % dextrose injections in 50 cc polyvinyl chloride (PVC) bags stored at 4 degrees Celsius and ambient temperature up to 24 hr was studied. Samples were analysed at 0, 4, 8, and 24 hr after preparing the controls and known mixtures, using a reversed phase stability indicating HPLC assay. The drug mixtures were stable up to 24 hrs as shown by the % remaining drug concentrations above 90 % at the respective sampling times.The pH of the drug solutions remained constant over time. These data support unequivocally the stability of zidovudine/dobutamine or zidovudine/ranitidine admixtures under the storage conditions studied in this investigation.
dc.languageeng
dc.publisheruga
dc.rightsOn Campus Only
dc.subjectPVC
dc.subjectHPLC
dc.subjectzidovudine
dc.subjectdobutamine
dc.subjectranitidine
dc.subjectambient temperature
dc.subjectand 4°C
dc.titleStability indicating studies of zidovudine and selected pharmaceuticals
dc.typeThesis
dc.description.degreeMS
dc.description.departmentCollege of Pharmacy
dc.description.majorPharmacy (Pharmaceutics)
dc.description.advisorEthan W. Taylor
dc.description.committeeEthan W. Taylor
dc.description.committeeJames T. Stewart
dc.description.committeeTony Capomacchia


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