Studies directed toward the synthesis of (+)- and (-)-Perovskone
Britton, Jonathan E
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In 1994 our group completed the first total synthesis of (±)-Perovskone, a complex triterpene natural product that was isolated from Perovskia abrotanoides in 1991. The key step in our synthesis featured a remarkable cascade of transformations in which three rings and five stereocenters were established in one operation. Herein, we report a more efficient, enantioselective synthetic route to a key intermediate to Perovskone.