Show simple item record

dc.contributor.authorWu, Dong F.
dc.date.accessioned2014-03-03T20:07:21Z
dc.date.available2014-03-03T20:07:21Z
dc.date.issued2001-12
dc.identifier.otherwu_dong_f_200112_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/wu_dong_f_200112_ms
dc.identifier.urihttp://hdl.handle.net/10724/20484
dc.description.abstractNucleosides have been studied as potential anti-viral and anti-cancer agents. A number of nucleosides have been discovered with significant antiviral activity. However, toxicities and side effects as well as the emergence of drug resistant viral strains limit the usefulness of the currently available nucleosides as anti-viral agents. Furthermore, the disadvantage of normal nucleosides and their analogs is that the glycosidic bond is subjected to enzymatic hydrolysis by phosphorylase. To overcome these problems, we need to synthesize new agents, among which are carbocyclic nucleoside analogs. In this thesis, the new carbocyclic L-Nucleoside with 5’-methylene group was synthesized and the new scheme was designed to synthesize the similar analogs.
dc.publisheruga
dc.rightspublic
dc.subjectCarbocyclic L-Nucleosides
dc.subjectEnzymatic Hydrolysis
dc.subjectAntiviral Agents
dc.subject5’-Methylene Group.
dc.titleSynthesis of carbocyclic L-Nucleosides
dc.typeThesis
dc.description.degreeMS
dc.description.departmentPharmaceutical and Biomedical Sciences
dc.description.majorNo Major
dc.description.advisorChung K. Chu
dc.description.committeeChung K. Chu
dc.description.committeeTony Capomacchia
dc.description.committeeRobert Lu


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record