Show simple item record

dc.contributor.authorNiecko, Timothy Edward
dc.date.accessioned2014-03-03T20:05:41Z
dc.date.available2014-03-03T20:05:41Z
dc.date.issued2001-12
dc.identifier.otherniecko_timothy_e_200112_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/niecko_timothy_e_200112_ms
dc.identifier.urihttp://hdl.handle.net/10724/20402
dc.description.abstractINTRODUCTION: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and is a growing health concern. Recently, epidemiological studies have associated NSAID use with a protective effect against CRC. METHODS: A retrospective, longitudinal, cohort design was used to assess the relationship of NSAID exposure and the incidence of CRC, gastrointestinal (GI), and renal adverse events in a Georgia Medicaid population. RESULTS: Over 700,000 person-years and 1.4 million drug claims were utilized. NSAID exposure reduced the risk of CRC by 25% and a dose/response relationship was confirmed with higher usage conferring more protection. Frequent users of NSAIDs did not experience an increased risk for GI and renal adverse events, though less frequent NSAID use trended toward an increase risk of GI events. CONCLUSION: This study confirms the NSAID/CRC protective relationship and found that long term NSAID use was not associated with an increase in GI and renal adverse events.
dc.publisheruga
dc.rightspublic
dc.subjectColon
dc.subjectRectal
dc.subjectColorectal
dc.subjectCancer
dc.subjectGastrointestinal
dc.subjectRena
dc.subjectNonsteroidal anti-inflammatory drug
dc.subjectAspirin
dc.subjectEpidemiology
dc.subjectMedicaid
dc.titleA pharmacoepidemiologic assessment of nonsteroidal anti-inflammatory drug exposure and the association withcolorectal cancer, gastrointestinal and renal adverse events
dc.typeThesis
dc.description.degreeMS
dc.description.departmentPharmaceutical and Biomedical Sciences
dc.description.majorPharmacy
dc.description.advisorBradley C. Martin
dc.description.committeeBradley C. Martin
dc.description.committeeJoseph DiPiro
dc.description.committeeJeffrey Kotzan


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record