Short-term treatment with an angiotensin converting enzyme inhibitor in cats with induced renal insufficiency

Abstract

The short-term effects of the angiotensin converting enzyme inhibitor spirapril on kidney function and systemic arterial blood pressure in cats (n = 24) with induced renal insufficiency. Renal mass was surgically reduced, cats were assigned to quartets of a 4 by 4 Latin square design. Cats were treated for 14 days at the following dosages: placebo,a 0.5 mg/kg spiraprilb (low), 1.0 mg/kg (medium), 2.0 mg/kg (high) given orally once daily. Arterial blood pressure, glomerular filtration rate (GFR), and renal plasma flow (RPF) were determined before treatment and the last day of each treatment period. Compared to treatment with placebo, mean GFR and RPF were not significantly affected by treatment with spirapril. Systemic arterial blood pressure did not significantly decrease in cats that received spirapril. The initiation of treatment with spirapril resulted in no adverse effects on GFR and RPF. Spirapril was an ineffective antihypertensive in cats with induced renal insufficiency.