The effects of iron and quercetin on apoptosis in a human hepotoma cell line
Mayer, William Boyd
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Quercetin, a flavonoid, is cytotoxic to human tumor cells at high concentrations. The objective of the present study was to determine if cellular iron status influences quercetin-stimulated cytotoxicity and apoptosis in a human hepatoblastoma cell line. To test the hypothesis, cell viability, lipid peroxidation, and apoptosis were measured in HepG2 cells following treatment with various levels of iron and quercetin. The data suggest that Fe concentration may influence quercetin’s effect on cell viability and apoptosis in HepG2 cells.