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dc.contributor.authorBowen, Nathan John
dc.date.accessioned2014-03-03T19:59:26Z
dc.date.available2014-03-03T19:59:26Z
dc.date.issued2000-12
dc.identifier.otherbowen_nathan_j_200012_phd
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/bowen_nathan_j_200012_phd
dc.identifier.urihttp://hdl.handle.net/10724/20114
dc.description.abstractRetrotransposons are the most abundant and widespread class of eukaryotic transposable elements (TEs). The recent genome sequencing of Caenorhabditis elegans and Drosophila melanogaster has provided an unprecedented opportunity to analyze the evolutionary relationships among the entire complement of retrotransposons within multicellular eukaryotic organisms. Here, I report the results of an analysis of retroviral-like long terminal repeat retrotransposons in C. elegans and D. melanogaster that indicate this class of elements may be even more abundant and divergent than previously expected. The unexpected presence, in C. elegans, of an element displaying a number of characteristics previously thought to be unique to vertebrate retroviruses suggests an ancient lineage for this important class of infectious agents. Likewise, the abundance and sequence identity of many retroviral elements within the D. melanogaster genome indicates that the majority of germ line transpositions have occurred in this species within the last 100,000 yrs. These results emphasize the dynamic nature of these elements and underscore their potential ability to influence the evolution of the host genomes in which they reside.
dc.publisheruga
dc.rightsOn Campus Only
dc.subjectTransposable Element
dc.subjectTE
dc.subjectLong Terminal Repeat Retrotransposon
dc.subjectLTR
dc.subjectRetrovirus
dc.subjectEvolution
dc.subjectGenome
dc.subjectGenomics
dc.subjectDrosophila melanogaster
dc.subjectCaenorhabditis elegans
dc.titleGenomic analysis of the retroviral elements of caenorhabditis elegans and drosophila melanogaster
dc.typeDissertation
dc.description.degreePhD
dc.description.departmentGenetics
dc.description.majorGenetics
dc.description.advisorJohn F. McDonald
dc.description.committeeJohn F. McDonald
dc.description.committeeJohn Avise
dc.description.committeeMichael Bender
dc.description.committeeKelly Dawe
dc.description.committeeSusan Wessler


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