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Synthesis and evaluation of mechanism based inhibitors of kynureninase ; asymmetric reductions of ethynylketones by secondary alcohol dehydrogenase from thermoanaerobacter ethanolicus
(uga, 1999-12)
In chapter I of this dissertation, the synthesis of some new inhibitors of the pyridoxal phosphate dependent enzyme kynureninase and the assessment of their kinetic parameters is described. Ten different compounds were ...